![]() We hope that by looking at the genome maintenance specifically in the context of ageing, we will gain insights into how chromosomal defects can be avoided, or even repaired during the aging process to ensure optimal cellular function and to promote lifelong health. This symposium brings together a diverse group of researchers using a breadth of experimental model systems and organisms with a focus on genome maintenance, from DNA repair to chromatin regulation. Together, a more complete understanding of these interactions will open doors for therapeutic interventions aimed to promote healthy ageing. Finally, we need to consider how time-dependent DNA alterations can impinge in gene expression and chromatin structure. Similarly, it will be vital to understand how the regulation of DNA repair and genome maintenance changes over the course of ageing. Therefore, to promote lifelong health it is critical to gain a better understanding of how DNA damage contributes to the ageing process and age-related disease. These molecular processes can impair cell function and alter cell fate thus contributing to disease, tissue and organ dysfunction thus driving the ageing process of the organism. The ensuing chromosomal alterations may lead to genome instability, somatic mutations, impaired gene expression and DNA replication, alterations of the epigenetic code and chromatin structure. Despite sophisticated genome maintenance mechanisms, DNA damage accumulates over time and hence with age. In contrast to any other macromolecule, the genome is irreplaceable and requires constant repair. Of the molecules that undergo changes over time, it is chromosomal alterations that may have some of the most profound and long-lasting cellular and organismal effects. ![]() “Time stands still for no one” or for no molecule, for that matter. It's a wonderful opportunity to network with people from other associations and societies around the world. It's significant that variations in the epitranscriptome's fundamental regulators are connected to a variety of human diseases and congenital abnormalities. This conference aims to present the most recent therapeutic perspectives that will be helpful across the spectrum of epitranscriptomics. The flexibility to achieve an enormous image of sickness and the way it affects individuals delivers a transparent image of the most human order. This is often helpful for analysis into organic process biology and also the treatment of hereditary diseases, because it simplifies the sophisticated development of epigenetic mechanisms and supermolecule expression. The study of chromosomes and also the quality of a life form's expression will reveal info concerning inheritance, hereditary mutations and changes. This workshop highlights studies using techniques as varied as single molecule physics and structural biology, pan-genomic analysis of chromosome structure and chromatin composition and live cell single particle tracking to uncover new findings on the nature of DNA topological transactions and how they impact cellular processes.Įpigenetics may be a whole trend at the ribonucleic acid space of biology and biological science, which investigates the structure and performance of genes at a molecular level. This generates a vibrant interdisciplinary meeting, which highlights and disseminates work involving diverse and rapidly evolving approaches. The EMBO workshops on DNA topology and topoisomerases bring together scientists who have only recently discovered the importance of DNA topology in their specialties with long-standing researchers in the field. ![]() We are also still deciphering how many chemotherapeutics target topoisomerases and DNA topology-impacted processes. Even after 70 years of research, novel roles for DNA topology and topoisomerase action in transcriptional control, chromosome structure, anti-viral responses, and genome stability are still being uncovered. Following the elucidation of the structure of DNA, it was clear that the iconic double helix structure of DNA would impact and impede the fundamental genomic transactions required for cellular life. ![]()
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